Double-blind, placebo-controlled, crossover study of the efficacy and safety of lisdexamfetamine dimesylate in college students with ADHD
Date of Original Version
Objective: To evaluate stimulant medication on symptoms and functioning for college students with ADHD using doubleblind, placebo-controlled, crossover design. Method: Participants included 24 college students with ADHD and 26 college students without psychopathology. Lisdexamfetamine dimesylate (LDX) was examined for ADHD participants over five weekly phases (no-drug baseline, placebo, 30-, 50-, and 70-mg LDX per day). Self-report rating scales of functioning and direct assessment of ADHD symptoms, verbal learning/memory, and adverse side effects were collected (baseline only for control students). Results: LDX was associated with large reductions in ADHD symptoms and improvement in executive functioning along with smaller effects for psychosocial functioning. Reduction in ADHD symptoms was found for 86.4% of participants; however, large differences in symptoms and executive functioning remained relative to controls. Conclusion: LDX is a safe, efficacious treatment for symptom relief in college students with ADHD. Research documenting medication effects on academic functioning and evaluating psychosocial/educational interventions is needed. © 2012 SAGE Publications.
Journal of Attention Disorders
DuPaul, George J., Lisa L. Weyandt, Joseph S. Rossi, Brigid A. Vilardo, Sean M. O'Dell, Kristen M. Carson, Genevieve Verdi, and Anthony Swentosky. "Double-blind, placebo-controlled, crossover study of the efficacy and safety of lisdexamfetamine dimesylate in college students with ADHD." Journal of Attention Disorders 16, 3 (2012): 202-220. doi:10.1177/1087054711427299.