Protection of dogs from lyme disease with a vaccine containing outer surface protein (Osp) A, OspB, and the saponin adjuvant QS21
Date of Original Version
A vaccine consisting of purified Escherichia coli-expressed recombinant full-length outer surface proteins A (OspA) and B (OspB) and the saponin adjuvant QS21 was evaluated for protection against Borrelia burgdorferi infection. Eleven beagles were vaccinated twice and then challenged with 10 field-collected adult female Ixodes scapularis. Xenodiagnosis revealed that all 11 nonvaccinated control dogs and 2 of 10 vaccinated dogs were infected with B. burgdorferi. Six of 11 control dogs also developed fever (0.75 ± 0.38°C) and were lethargic. One of the control dogs also developed a limp. Both of the infected vaccinated dogs were asymptomatic. Thus, the vaccine prevented tick-vectored infection and associated symptoms of Lyme disease. © 1995, by The University of Chicago.
Publication Title, e.g., Journal
Journal of Infectious Diseases
Coughlin, Richard T., Durland Fish, Thomas N. Mather, Jianneng Ma, Charles Pavia, and Patrice Bulger. "Protection of dogs from lyme disease with a vaccine containing outer surface protein (Osp) A, OspB, and the saponin adjuvant QS21." Journal of Infectious Diseases 171, 4 (1995). doi: 10.1093/infdis/171.4.1049.