Date of Award
Doctor of Philosophy in Interdisciplinary Neuroscience
Walter G. Besio
Knowing where sources of electroencephalography (EEG) signals are located in the brain can help with diagnosis and surgical planning for patients with epilepsy. Source localization of signals acquired on the scalp is an ill-posed problem since there are an infinite number of inverse configurations that can result in the same potential distribution on the head surface. Therefore, additional constraints to the source space must be used to find a unique solution. Distributed source methods constrain the source space to a large number of dipoles distributed on the cortical surface or within the brain, but they yield an underdetermined solution. Used with conventional EEG and its limited spatial resolution, these localization methods produce poor resolution. There exists a need to better localize sources of activity measured on the scalp before the use of invasive procedures and their risks. Tripolar EEG (tEEG), i.e., EEG recorded with the tripolar concentric ring electrode (TCRE), has increased spatial resolution and signal-to-noise ratio, and it more readily detects high frequency biomarkers of epileptogenic zones than conventional, noninvasive measurements. This research explores the effects of these tEEG advantages on localization with distributed source methods and its potential in clinical use.
Toole, Christopher, "Source Localization of Tripolar Electroencephalography" (2018). Open Access Dissertations. Paper 714.