The major components of human energy balance during chronic β-adrenergic blockade
Date of Original Version
Purpose: The authors compare the major components of energy balance - dietary food intake, resting metabolic rate, and physical energy expenditure - in patients receiving β-blocking medications and healthy controls. Methods: The authors recruited subjects who were receiving β-blocking agents (n = 22) from local hospitals and clinics. Twenty-two healthy controls were matched to each patient based on age, weight, and gender. Resting metabolic rates were determined using indirect calorimetry. Three-day dietary intakes and physical activity assessments were analyzed. Results: There were no between-group differences in calories ingested or self-reported physical activity patterns. However, resting metabolic rates were lower in the beta-blocked subjects (β-blocked = 1,541 ± 464 kcals/day; controls = 1,817 ± 426 kcals/day; P < 0.05). Conclusions: β-adrenergic blockade causes a reduction in resting metabolic rate. Therefore, β-blocked individuals should increase physical activity, decrease dietary intake, or both to maintain daily energy balance and prevent weight gain that accompanies a reduction in metabolic rate.
Journal of Cardiopulmonary Rehabilitation
Lamont, L. S., T. Brown, D. Riebe, and M. Caldwell. "The major components of human energy balance during chronic β-adrenergic blockade." Journal of Cardiopulmonary Rehabilitation 20, 4 (2000): 247-250. doi:10.1097/00008483-200007000-00006.