Transcranial focal stimulation via concentric ring electrodes reduced power of pentylenetetrazole-induced seizure activity in rat electroencephalogram
Date of Original Version
As epilepsy affects approximately one percent of the world population, electrical stimulation of the brain has recently shown potential for additive seizure control therapy. In this study we applied noninvasive transcranial focal stimulation (TFS) via concentric ring electrodes on the scalp of rats after inducing seizures with pentylenetetrazole (PTZ) to assess the effect of TFS on the electrographic activity. Grand average power spectral densities were calculated to compare different stages of seizure development. They showed a significant difference between the TFS treated group and the control group. In case of the TFS treated group, after TFS, the power spectral density was reduced further towards a pre-seizure baseline than it was for the control group. The difference is the most drastic in delta, theta and alpha frequency bands. Application of general likelihood ratio test showed that TFS significantly (p0.001) reduced the power of electrographic seizure activity in the TFS treated group compared to controls in more than 86% of the cases. These results suggest that TFS may have an anticonvulsant effect. © 2011 IEEE.
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Makeyev, Oleksandr, Xiang Liu, Kanthaiah Koka, Steven M. Kay, and Walter G. Besio. "Transcranial focal stimulation via concentric ring electrodes reduced power of pentylenetetrazole-induced seizure activity in rat electroencephalogram." Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS , (2011): 7560-7563. doi:10.1109/IEMBS.2011.6091864.