Title

Recent advances in the discovery of Src kinase inhibitors

Document Type

Article

Date of Original Version

9-1-2005

Abstract

Src family kinases are involved in the regulation of a wide variety of normal cellular signal transduction pathways, such as cell growth, differentiation, survival, adhesion and migration. Considerable evidence implicates elevated expression and/or activity of Src kinases in many human cancers, osteoporosis, cardiovascular disorders and immune system dysfunction; thus, this family of protein tyrosine kinases now exists as intriguing targets for both basic research and drug discovery. Herein, a number of examples of currently developed Src family kinase inhibitors in selected patents from 2002 - 2005 will be described. Special attention will be made to the chemical diversity of ATP binding site inhibitors, potency, selectivity and therapeutic application of the compounds. © 2005 Ashley Publications Ltd.

Publication Title, e.g., Journal

Expert Opinion on Therapeutic Patents

Volume

15

Issue

9

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