Evaluation of the sensitivity of Pseudomonas aeruginosa to the immediate and delayed bactericidal effects of normal human serum
Date of Original Version
A survey was conducted to examine clinical and environmental isolates of Pseudomonas aeruginosa for sensitivity to the immediate (1 hr) and delayed (3 hr) bactericidal effects of normal human serum. The majority of isolates (88.5%) were found to be resistant to all bactericidal activity and were able to grow in the presence of 10% normal human serum. No difference in sensitivity was observed when clinical and environmental isolates were compared. The remaining organisms demonstrated varying degrees of sensitivity. An examination of the role of the classical and alternate pathways of complement activation revealed that a portion of the serum sensitive strains activated complement via the classical pathway only, while others were capable of activating the alternate pathway. Unlike previous studies concerning E. coli and Serratia, no clear relationship was observed between the overall sensitivity of a given strain and the ability to activate a particular pathway.
Publication Title, e.g., Journal
IRCS Medical Science
Laxon, J. H., and D. C. Laux. "Evaluation of the sensitivity of Pseudomonas aeruginosa to the immediate and delayed bactericidal effects of normal human serum." IRCS Medical Science 9, 11 (1981): 1012-1013. https://digitalcommons.uri.edu/cmb_facpubs/280