Title

The Role of Design, Serendipity, and Scientific Competition in the Development of Oxidative Coupling Reactions

Document Type

Article

Date of Original Version

1-1-2015

Abstract

This account describes the development of novel reactions for the formation of both carbon-carbon (C-C) and carbon-nitrogen (C-N) bonds. Each of the reactions involves dual C-H/C-H or C-H/N-H activation mechanisms and an organic or inorganic oxidant. The development of these novel reactions involved the interplay of both serendipity and design and was motivated by both scientific curiosity and competition. Ultimately, regioselective oxidative arylation and amination reactions were discovered and their mechanisms were elucidated, allowing the author and his research team to map out the chemical reactivity of a variety of arenes and amines in oxidizing conditions.

Publication Title

Strategies and Tactics in Organic Synthesis

Volume

11

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