C-C bond formation via double C-H functionalization: Aerobic oxidative coupling as a method for synthesizing heterocoupled biaryls

Timothy A. Dwight, University of Rhode Island
Nicholas R. Rue, University of Rhode Island
Dagmara Charyk, University of Rhode Island
Ryan Josselyn, University of Rhode Island
Brenton DeBoef, University of Rhode Island

Abstract

The aerobic oxidative coupling of arenes such as benzofuran and N-substituted indoles with benzene and derivatives thereof is described. The reaction is shown to take place in both inter- and intramolecular scenarios. © 2007 American Chemical Society.