Oxidant-controlled regioselectivity in the oxidative arylation of N-acetylindoles
Abstract
N-Acetylindoles can be oxidatively coupled with arenes such as benzene or pentafluorobenzene in dioxane. The use of Cu(OAc)2 as the stoichiometric oxidant produces selective arylation at the 3-position of indole while AgOAc produces selective arylation at indole's 2-position. © 2008 Elsevier Ltd. All rights reserved.
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