Regioselective C-H bond amination by aminoiodanes

Abhishek A. Kantak, University of Rhode Island
Louis Marchetti, University of Rhode Island
Brenton Deboef, University of Rhode Island


A new approach for the direct amination of 2-phenylpyridine derivatives using a diphthalimide-iodane and copper triflate has been developed. A series of different 2-phenylpyridine derivatives were aminated with yields up to 88%. Mechanistic investigations indicate that the reaction proceeds via a copper-mediated single electron transfer. This journal is