Microwave assisted vacuum drying and end point determination using mass spectrometry, Part I
Date of Original Version
On-line mass spectrometry (MS) was investigated as a tool to monitor microwave vacuum drying operations on laboratory scale. Using several different solvents and calcium carbonate solids, MS was used to monitor the drying end point of single and multiple solvent wet cakes. The microwave drying rates for polar solvents were shown to have a linear correlation with solvent heat of vaporization. Mass spectrometry profiles were also shown to correlate with other drying end point parameters, including rate of recovered solvent, product temperature, and microwave reflected power.
Organic Process Research and Development
Hettenbach, Kevin, David J. J. Am Ende, Eric Dias, Steven J. Brenek, Catherine Laforte, and Stanley M. Barnett. "Microwave assisted vacuum drying and end point determination using mass spectrometry, Part I." Organic Process Research and Development 8, 6 (2004): 859-866. doi:10.1021/op0498565.