Title

Bilayer heating in magnetite nanoparticle-liposome dispersions via fluorescence anisotropy

Document Type

Article

Date of Original Version

5-1-2011

Abstract

Temperature measurements have been made within magnetite (Fe3O4) nanoparticle-liposome dispersions subjected to electromagnetic field at radiofrequency (RF) heating based on the fluorescence anisotropy of diphenylhexatriene (DPH) embedded within the bilayer. Incorporating cholesterol within dipalmitoylphosphatidylcholine (DPPC) bilayers broadened the anisotropy window associated with lipid melting. Cryogenic transmission electron microscopy showed that the dispersions contained magnetoliposomes with nanoparticle aggregates at both low and high encapsulation densities. RF heating results demonstrated the ability to measure the temperature of the ML bilayer with on/off RF cycles using DPH anisotropy. These measurements reflected the temperature of the bulk aqueous phase, which is consistent with previous work showing rapid heat dissipation from a nanoparticle surface during RF heating and a negligible difference between surface and bulk temperature. © 2011 Elsevier Inc.

Publication Title

Journal of Colloid and Interface Science

Volume

357

Issue

1

Share

COinS