Title

Nanocomposite microparticles (ncmp) for pulmonary drug delivery applications

Document Type

Article

Date of Original Version

1-1-2017

Abstract

Despite the many advances in drug delivery and pulmonary therapeutics, the lungs present a challenge where physiological barriers need to be overcome in order to facilitate effective delivery of active pharmaceutical ingredients. Nanocomposite microparticles (nCmP) have the potential to overcome the physiological limitations of the lungs. Comprised of nanoparticles (NP) entrapped or encapsulated into a microparticle system, nCmP are dry powder aerosols that can deposit in various areas of the lungs depending on their size. Once the nCmP reach the lungs, they decompose into their native NP, allowing for delivery of a therapeutic encapsulated in the NP. The microparticle size allows for effective pulmonary delivery while the NP allow for the effective penetration into physiological barriers such as the mucosa and/or pulmonary epithelium. This book chapter outlines the advantages, methods of preparation, optimization, drug release, and applications of nCmP.

Publication Title

Drug Delivery Approaches and Nanosystems: Volume 2: Drug Targeting Aspects of Nanotechnology

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