Date of Original Version
Biochemistry, Microbiology and Molecular Genetics
Staphylococcus epidermidis is a major cause of infections associated with indwelling medical devices. Biofilm production is an important virulence attribute in the pathogenesis of device-related infections. Therefore, elimination of these biofilms is an ideal treatment. Salicylate (5 mM) combined with 1 μg of vancomycin per ml inhibited biofilm formation by S. epidermidis (RP62A) by ≥99.9%. When biofilm-coated polystyrene beads were exposed to 5 mM sodium salicylate and 4 μg of vancomycin per ml (one-half the minimum biofilm eradication concentration), there was a >99.9% reduction in viable count.
Polonio, R. E., Mermel, L. A., Paquette, G. E., & Sperry, J. F. (2001). Eradication of Biofilm-Forming Staphylococcus epidermidis (RP62A) by a Combination of Sodium Salcylate and Vancomycin. Antimicrobial Agents and Chemotherapy, 45(11), 3262-3266. doi: 10.1128/AAC.45.11.3262-3266.2001
Available at: http://dx.doi.org/10.1128/AAC.45.11.3262-3266.2001