Title
Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds
Document Type
Article
Date of Original Version
2-24-2017
Abstract
Fifteen new phloroglucinol derivatives, jamunones A-O (1-8 and 10-16, respectively), along with one known analogue spiralisone C (9), were isolated from Eugenia jambolana seeds. Their structures were elucidated by detailed nuclear magnetic resonance and mass spectrometry spectroscopic data interpretation. Compounds 1-9, 11, 12, and 14-16 inhibited protein tyrosine phosphatase 1B activity with IC50 values ranging from 0.42 to 3.2 μM.
Publication Title, e.g., Journal
Journal of Natural Products
Volume
80
Issue
2
Citation/Publisher Attribution
Liu, Feifei, Tao Yuan, Wei Liu, Hang Ma, Navindra P. Seeram, Yuanyuan Li, Li Xu, Yu Mu, Xueshi Huang, and Liya Li. "Phloroglucinol Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activities from Eugenia jambolana Seeds." Journal of Natural Products 80, 2 (2017): 544-550. doi: 10.1021/acs.jnatprod.6b01073.