Celosiadines A and B, unusual guanidine alkaloids from Iresine diffusa
Date of Original Version
Two unusual di-isopentenyl guanidine alkaloids, named celosiadines A (1) and B (2), were isolated from Iresine diffusa aerial parts. The structures of the compounds were elucidated from extensive spectroscopic analyses including HRMS, NMR and ECD. Celosiadines A and B showed favorable binding affinity to the androgen receptor (AR) in silico and were cytotoxic towards AR-sensitive (LNCaP) but not AR-insensitive (PC3) human prostate cancer cells in vitro.
Natural Product Research
Killian, Caroline, Shelby L. Johnson, Hang Ma, Brendan McKeown, Luke McDougall, Robert Hurta, Yongqiang Liu, and Navindra P. Seeram. "Celosiadines A and B, unusual guanidine alkaloids from Iresine diffusa." Natural Product Research 36, 1 (2021): 356-360. doi:10.1080/14786419.2020.1784174.