DNA-binding studies of the natural β-carboline eudistomin U
Date of Original Version
Eudistomin U is a member of the β-carboline class of heterocyclic amine-containing molecules that are capable of binding to DNA. The structure of eudistomin U is unique since it contains an indole ring at the 1-position of the pyridine ring. While simple β-carbolines are reported to intercalate DNA, an examination of the mode of binding of eudistomin U has been lacking. We report preliminary spectroscopic (UV–Vis, thermal denaturation, CD) and calorimetric (DSC) data on the binding of eudistomin U to DNA, which suggest that eudistomin U binds weakly according to a mechanism that is more complicated than other members of its class.
Bioorganic and Medicinal Chemistry Letters
Giulietti, Jennifer M., Patrick M. Tate, Ang Cai, Bongsup Cho, and Seann P. Mulcahy. "DNA-binding studies of the natural β-carboline eudistomin U." Bioorganic and Medicinal Chemistry Letters 26, 19 (2016): 4705-4708. doi:10.1016/j.bmcl.2016.08.047.