Document Type
Article
Date of Original Version
2019
Department
Biomedical and Pharmaceutical Sciences
Abstract
Quorum sensing (QS) antagonists have been proposed as novel therapeutic agents to combat bacterial infections. We previously reported that the secondary metabolite 3-methyl-N-(2′-phenylethyl)-butyramide, produced by a marine bacterium identified as Halobacillus salinus, inhibits QS controlled phenotypes in multiple Gram-negative reporter strains. Here we report that N-phenethyl hexanamide, a structurally-related compound produced by the marine bacterium Vibrio neptunius, similarly demonstrates QS inhibitory properties. To more fully explore structure–activity relationships within this new class of QS inhibitors, a panel of twenty analogs was synthesized and biologically evaluated. Several compounds were identified with increased attenuation of QS-regulated phenotypes, most notably N-(4-fluorophenyl)-3-phenylpropanamide against the marine pathogen Vibrio harveyi (IC50 = 1.1 µM). These findings support the opportunity to further develop substituted phenethylamides as QS inhibitors.
Citation/Publisher Attribution
Meschwitz, S. M., Teasdale, M. E., Mozzer, A., Martin, N., Liu, J., Forschner-Dacause, S., & Rowley, D. C. (2019). Antagonism of Quorum Sensing Phenotypes by Analogs of the Marine Bacterial Secondary Metabolite 3-Methyl-N-(2′-Phenylethyl)-Butyramide. Marine Drugs, 17(7), 389. doi:10.3390/md17070389
Available at: https://doi.org/10.3390/md17070389
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.