Date of Original Version
Biomedical and Pharmaceutical Sciences
A series of half-sandwich arene ruthenium complexes containing bidentate thiosemicarbazone ligands have been synthesized and their biological activity investigated. The compounds have the general formula [(6-p-cymene)Ru(R-ATSC)Cl]X (ATSC = 9-anthraldehyde thiosemicarbazone and R = H, CH3 and C6H5). The crystal structure of [(6-p-cymene) Ru(MeATSC)Cl]Cl have been determined and represents the first structurally characterized arene–ruthenium half-sandwich complex with a thiosemicarbazone ligand. The complexes show good cytotoxic profiles against MCF-7 and MDA-MB-231 (breast adenocarcinoma) as well as HCT 116 and HT-29 (colorectal carcinoma) cell lines.
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Beckford, F. A., Leblanc, G., Thessing, J., Shaloski, M., Jr., Frost, B. J., Li, L., & Seeram, N. P. (2009). Organometallic ruthenium complexes with thiosemicarbazone ligands: Synthesis, structure and cytotoxicity of [(η6-p-cymene)Ru(NS)Cl]+ (NS = 9-anthraldehyde thiosemicarbazones). Inorganic Chemistry Communications, 12(11), 1094-1098. doi: 10.1016/j.inoche.2009.08.034
Available at: https://doi.org/10.1016/j.inoche.2009.08.034
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