Date of Original Version
Biomedical and Pharmaceutical Sciences
A series of two classes of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates were synthesized using click chemistry approach. All compounds were evaluated for inhibition of Src kinase and human ovarian adenocarcinoma (SK-Ov-3), breast carcinoma (MDA-MB-361), and colon adenocarcinoma (HT-29). Hexyl triazolyl-substituted 3-phenylpyrazolopyrimidine exhibited inhibition of Src kinase with an IC50 value of 5.6 μM. 4-Methoxyphenyl triazolyl-substituted 3-phenylpyrazolopyrimidine inhibited the cell proliferation of HT-29 and SK-Ov-3 by 73% and 58%, respectively, at a concentration of 50 μM.
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Kumar, A., Ahmad, I., Chhikara, B. S., Tiwari, R., Mandal, D., & Parang, K. (2011). Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities. Bioorganic & Medicinal Chemistry Letters, 21(5), 1342-1346. doi: 10.1016/j.bmcl.2011.01.047
Available at: https://doi.org/10.1016/j.bmcl.2011.01.047
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