Date of Original Version
Biomedical and Pharmaceutical Sciences
A series of twenty two novel 1-cyclopropyl-6-fluoro-4-oxo-7-(4-substituted piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid analogues have been synthesized, characterized (1H NMR, 13C NMR and LCMS) and evaluated for their inhibitory activity on the proliferation of human caucasian acute lymphoblastic leukemia cells (CCRF-CEM), breast adenocarcinoma cells (MDA-MB-468) and human colon carcinoma cells (HCT-116). Among all the synthesized ciprofloxacin analogues 3t at 50 μM showed comparable potency to doxorubicin (10 μM) in all three cell lines and 3j inhibited proliferation of MDA-MB-468 up to 35% selectively over other two cell lines.
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Suresh, N., Nagesh, H. N., Sekhar, K. V. G. C., Kumar, A., Shirazi, A. N., & Parang, K. (2013). Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines. Bioorganic & Medicinal Chemistry Letters, 23(23), 6293-6295. doi: 10.1016/j.bmcl.2013.09.077
Available at: https://doi.org/10.1016/j.bmcl.2013.09.077
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