Date of Original Version
Biomedical and Pharmaceutical Sciences
Simple and efficient synthesis of quebecol and a number of its analogs was accomplished in five steps. The synthesized compounds were evaluated for antiproliferative activities against human cervix adenocarcinoma (HeLa), human ovarian carcinoma (SK-OV-3), human colon carcinoma (HT-29), and human breast adenocarcinoma (MCF-7) cancer cell lines. Among all the compounds, 7c, 7d, 7f, and 8f exhibited antiproliferative activities against four tested cell lines with inhibition over 80% at 75 μM after 72 h, whereas, compound 7b and 7g were more selective towards MCF-7 cell line. The IC50 values for compounds 7c, 7d, and 7f were 85.1 μM, 78.7 μM, and 80.6 μM against MCF-7 cell line, respectively, showing slightly higher antiproliferative activtiy than the synthesized and isolated quebecol with an IC50 value of 104.2 μM against MCF-7.
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Pericherla, K., Shirazi, A. N., Rao, V. K., Tiwari, R. K., DaSilva, N., McCaffrey, K. T., Beni, Y. A.,...Kumar, A. (2013). Synthesis and antiproliferative activities of quebecol and its analogs. Bioorganic & Medicinal Chemistry Letters, 23(19), 5329-5331. doi: 10.1016/j.bmcl.2013.07.058
Available at: https://doi.org/10.1016/j.bmcl.2013.07.058
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