Date of Award

1978

Degree Type

Thesis

Degree Name

Master of Science in Pharmacy

Department

Pharmacy

First Advisor

George E. Osborne

Abstract

The effect of formulation factors on the efficacy of the antiperspirant agent, aluminum chlorhydrate, was studied. The formulation variables include the various carrier vehicles for the topically applied active ingredient. Quantification of antiperspirant efficiency was evaluated by a generally accepted gravimetric technique by application of a known amount of active ingredient to the axillae of human volunteers. Aluminum chlorhydrate was solubilized in a cream base, an aqueous lotion, and a hydroalcholic base, and was suspended in a solid stick. Aluminum chlorhydroxy allantoinate was incorporated into all vehicles for its therapeutic and cosmetic properties. All test antiperspirant products were selected on the basis of cosmetic elegance and acceptability. The four vehicles containing aluminum chlorhydrate were compared for efficacy by a well recognized gravimetric procedure during a normal work day in each subject's normal work environment. A pretest sweat collection was used as a blocking factor in designing the 4 by 4, split plot, Latin Square. Post-test sweat collection data were evaluated statistically using the geometric mean of treatment results. All ratio treatment means were converted to percent sweat reduction to determine antiperspirant efficiency. The carrier vehicle does not affect antiperspirant efficacy. However, efficacy differences were observed as a function of solution versus suspension. Treatment response in terms of percent sweat reduction was: aqueous lotion, 38.%; hydroalcoholic solution, 32.4%; cream base, 31.8%, and solid stick, -6.2%. Statistical analysis indicated that the side treated may be selected randomly without compromising the results. Sweat weights may be affected by temperature, muscular exercise, or emotional stress without affecting antiperspirant effectiveness.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.