Date of Award

1966

Degree Type

Thesis

Degree Name

Master of Science in Pharmacology

Department

Pharmacology

First Advisor

John J. DeFeo

Abstract

Derivatives of cyclohexanol were screened for pharmacological effects on intact anesthetized rats, isolated guinea pig heart, isolated rat atria and isolated rabbit small intestine. All the compounds tested produced a hypotensive response and cardio-inhibitory effects varying from slight depression to complete arrest. On the basis of recovery from induced cardiac arrest none of the compounds appeared to be cardio-toxic. All the compounds produced inhibitory effects on the isolated small intestine in varying degrees. Methyl 3-hydroxy-2-o-tolylcyclohexylacetate and trans-3-oxo-2-o-tolylcyclohexylacetic acid were equally potent and the most effective in their cardiovascular effects whereas the ketal from glycerol and 2-o-tolylcyclohexylacetate was the most effective on the isolated rabbit small intestine. Studies of mechanism, employing the isolated rat atria, indicate an antagonistic effect between these compounds and calcium.

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