Date of Award

1966

Degree Type

Thesis

Degree Name

Master of Science in Pharmacy

Department

Pharmaceutical Sciences

First Advisor

James C. Price

Abstract

Stability of procaine and potassium salts of penicillin G in oleaginous materials containing colloidal silica was studied. The instability of penicillin G in these bases seemed to be due primarily to the surface acidity or the silica in conjunction with the ester constituents of oils. The stability or the peanut oil/silica/penicillin G preparations could be improved by reducing the surface acidity of the silica by esterification. Dehydration of the silica also gave formulations with improved stability, but with unacceptable rheological properties. The color reactions of procaine penicillin G/silica/oleaginous materials appeared to be unrelated to the stability of the drug and might be due to interactions of procaine with traces of aldehydes present in the oily materials.

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