Title

Tracing molecular dephasing in biological tissue

Authors

Mohammad Mokim, University of Rhode Island
Chris Carruba, University of Rhode Island
Feruz Ganikhanov, University of Rhode IslandFollow

Document Type

Article

Date of Original Version

2017

Abstract

We demonstrate the quantitative spectroscopic characterization and imaging of biological tissue using coherent time-domain microscopy with a femtosecond resolution. We identify tissue constituents and perform dephasing time (T₂) measurements of characteristic Raman active vibrations. This was shown in subcutaneous mouse fat embedded within collagen rich areas of the dermis and the muscle connective tissue. The demonstrated equivalent spectral resolution (-1) is an order of magnitude better compared to commonly used frequency-domain methods for characterization of biological media. This provides with the important dimensions and parameters in biological media characterization and can become an effective tool in detecting minute changes in the bio-molecular composition and environment that is critical for molecular level diagnosis.

Citation/Publisher Attribution

Mokim, M., Carruba, C. & Ganikhanov. (2017). Tracing molecular dephasing in biological tissue. Appl. Phys. Lett. 111, 183701. doi: 10.1063/1.5001813

Available at: http://dx.doi.org/10.1063/1.5001813