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Optoacoustic tomography has been used for the detection of pancreatic ductal adenocarcinoma targeted by pH-Low Insertion Peptide (pHLIP) conjugated to near infrared fluorescent dye. It was proved that tumor targeting is a pH-dependent. The approach could have major implication for detection and monitoring of pancreatic and other cancers.
Reshetnyak YK. (2015). "Imaging Tumor Acidity: pH-Low Insertion Peptide Probe for Optoacoustic Tomography." Forthcoming in Clincal Cancer Research. Available at: http://clincancerres.aacrjournals.org/content/early/2015/07/29/1078-0432.CCR-15-1502.abstract