Document Type
Article
Date of Original Version
2016
Department
Pharmacy Practice
Abstract
Background:
Prospective audit and feedback is a core antimicrobial stewardship program (ASP) strategy; however its impact is difficult to measure.
Methods:
Our quasi-experimental study measured the effect of an ASP on clinical outcomes, antimicrobial use, resistance, costs, patient safety (adverse drug events [ADE] and Clostridium difficile infection [CDI]), and process metrics pre- (9/10–10/11) and post-ASP (9/12–10/13) using propensity adjusted and matched Cox proportional-hazards regression models and interrupted time series (ITS) methods.
Results:
Among our 2,696 patients, median length of stay was 1 day shorter post-ASP (5, interquartile range [IQR] 3–8 vs. 4, IQR 2–7 days, p
Conclusions:
Prospective audit and feedback has the potential to improve antimicrobial use and outcomes, and contain bacterial resistance. Our program demonstrated a trend towards decreased length of stay, broad-spectrum antimicrobial use, antimicrobial costs, and adverse events.
Citation/Publisher Attribution
Morrill HJ, Caffrey AR, Gaitanis MM, LaPlante KL. (2016) Impact of a Prospective Audit and Feedback Antimicrobial Stewardship Program at a Veterans Affairs Medical Center: A Six-Point Assessment. PLoS ONE 11(3): e0150795. doi:10.1371/journal.pone.0150795
Available at: http://dx.doi.org/10.1371/journal.pone.0150795
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