Document Type

Article

Date of Original Version

2015

Abstract

Pharmacodynamic activity in antibiotic combinations of daptomycin, vancomycin and linezolid was investigated in a 48h in vitro pharmacodynamic model. Using free human-simulated concentrations, activity against clinical biofilm-forming methicillin-resistant Staphylococcus aureus isolates was evaluated. Linezolid antagonized vancomycin activity at 24 and 48h. Linezolid antagonized daptomycin at 24 and 48h depending on dose and strain. Adding daptomycin increased vancomycin activity at 48h (p<0.03). These results may be strain-dependent and require further clinical investigation.

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