Date of Award
Doctor of Philosophy (PhD)
Over the past two decades, drug delivery systems have become a subject of major interest in the pharmaceutical industry for the treatment of different diseases, such as cancer, viral infections, and genetic disorders. A wide range of compounds show high binding affinity and great potential in in vitro non-cellular assays through direct interacting with molecular targets. However, many compounds show low potency in cell-based assays due to their limited delivery across the cell membrane. The physicochemical properties of several compounds, such as size, poor water solubility, hydrophobic nature, and negative charge, limit their cellular uptake significantly. Thus, there is an urgent need in design and synthesis of novel molecular transporters for efficient delivery of effective compounds to cellular targets.
Nasrolahi Shirazi, Amir, "Cyclic Peptides: Design, Characterization, Self-Assembly, and Applications as Nano Drug Delivery Systems" (2013). Open Access Dissertations. Paper 66.