Date of Award

1966

Degree Type

Dissertation

Degree Name

Doctor of Philosophy in Pharmaceutical Sciences

Department

Interdepartmental Program

Abstract

The hypothesis that solid particles may be encapsulated by coacervation led to the investigation of the extractability of microcapsules, which contained solids, by gastrointestinal fluids. Starting pH, starting temperature, ratio of solid to encapsulating materials, quantity of denaturant, and final pH were varied. In addition a surfactant and dispersant were added to selected series. The effects of the variables and additives on microcapsules were determined by submitting samples to simulated gastrointestinal fluids for periods of up to two and one-half hours and then comparing the extracts spectrophotometrically to know absorption spectra. Results showed that all variables and additives effected some degree of change in microcapsules.

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