Date of Original Version
Tuberculosis (TB) cellular immune responses were examined in breastmilk of HIV-infected mothers using the T-SPOT.TB interferon gamma release assay (IGRA). Positive TB IFN-γ responses were detected in 6 of 8 (75%) valid breast milk assays. Among 7 mothers with paired breastmilk and blood assays, TB IFN- γ responses were higher in breastmilk compared to blood (p=.02). The magnitude of TB IFN-γ responses in maternal breastmilk and blood were correlated. Elucidating the influence of breastmilk TB immune responses on infant TB susceptibility and immunity may inform future maternal TB vaccine strategies.
Cranmer, L.M. et al. "Tuberculosis interferon-gamma responses in the breast milk of human immunodeficiency virus infected mothers." The International Journal of Tuberculosis and Lung Disease. December 5, 2014. Available: http://dx.doi.org/10.5588/ijtld.14.0384