Iron-catalyzed arylation of heterocycles and transition-metal free C-N bond formation

John Joseph Sirois, University of Rhode Island

Abstract

The formation of carbon-carbon (C-C) and carbon-nitrogen (C-N) bonds is discussed and efforts towards expanding the known reactions of this type are the primary focus of this work. The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes and furans has been achieved. The use of an imine directing group allowed for the ortho-functionalization of these heterocycles with complete conversion in 15 minutes at 0 °C. Yields up to 88% were observed in the synthesis of 15 heterocyclic biaryls. C-N bond formation is achieved using aryl Grignard reagents and N-chloroamines at -78 °C.^

Subject Area

Chemistry|Organic chemistry

Recommended Citation

John Joseph Sirois, "Iron-catalyzed arylation of heterocycles and transition-metal free C-N bond formation" (2015). Dissertations and Master's Theses (Campus Access). Paper AAI3718831.
http://digitalcommons.uri.edu/dissertations/AAI3718831

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