Uncovering orthologous genes of the Ciona intestinalis Fanconi Anemia pathway

Edward Stanley, University of Rhode Island

Abstract

Fanconi Anemia is a disease caused by any number of mutations in a collection of DNA double-strand repair genes. In silico tests were performed to determine whether any of these genes were conserved in Ciona, which split from humans over 500 million years ago. Among the 22 gene products tested, evidence for 10 orthologs were discovered. Possible orthologs were seen in all three of the major groups of FA proteins.^

Subject Area

Biology, Genetics|Biology, Bioinformatics

Recommended Citation

Edward Stanley, "Uncovering orthologous genes of the Ciona intestinalis Fanconi Anemia pathway" (2015). Dissertations and Master's Theses (Campus Access). Paper AAI1582904.
http://digitalcommons.uri.edu/dissertations/AAI1582904

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