Smartphone integration and fluid flow control in a hand-held microfluidic lab-on-chip biosensor
This experimental study investigates the possibility of creating two separate systems for a Point-of-Care (POC), Lab-on-a Chip (LOC) handheld biosensor for the detection of C-reactive protein (CRP). One of these systems is a fluid control system that would facilitate the automation of the pumping of liquid, for a test for CRP. This fluid control system would use a Charged Couple Device (CCD) as a way to monitor the detection site for any changes. The microfluidic system that is used is fabricated from Polydimethylsiloxane (PDMS) and is either bonded to another piece of PDMS or a thin glass base. ^ The second system that this research aims to create is a wireless system that could exhibit complete control over the handheld unit. This system will use a custom iPhone application (app) for the graphics user interface (GUI), and will be able to send data to start a test, as well as receive the results after the completion of a test. For the first time, a completely automated, reliable, and inexpensive fluid handling system will be presented. As will the ability for a smartphone to operate a handheld microfluidic device test for CRP.^
Nicholas M Difilippo,
"Smartphone integration and fluid flow control in a hand-held microfluidic lab-on-chip biosensor"
Dissertations and Master's Theses (Campus Access).