The synthesis of rotaxane probes for magnetic resonance imaging (MRI)

Scott MacGill Karas, University of Rhode Island


Rotaxanes are simple molecules made by an interaction between a host and a guest.1 Research has shown rotaxanes have the capability of exchanging a hyperpolarized inert gas atom for use in Magnetic Resonance Imaging (MRI).2 In the past, MRIs were completed by the injecting a radioactive element Gadolinium (III) (Gd(III)) into the human body to act a contrasting agent.3 Unfortunately, these contrast agents are expensive and toxic to the body; as a result, there is need for a cheaper and less toxic imaging agent. These macromolecules can be synthesized to bind a specific protein, tumor, or cell within the body. Combining rotaxanes with Hyperpolarized 129Xe Chemical Exchange Saturation Transfer (HyperCEST), 129Xe MRI technology is capable of imaging specific areas in the human anatomy allowing for further study and diagnosis of diseases or injuries. Currently 129Xe MRI is being used capture images in the lungs and the brain but with a synthetic molecule we hope to broaden this capability. The manuscript, ?Cyclodextrin-based Pseudo-rotaxanes: An Easily Conjugatable Scaffold for Hyperpolarized Xenon Magnetic Resonance Imaging Biosensors? is the result of the preliminary work to develop a viable molecular probe. The manuscript focuses on using ?-cyclodextrin to develop a pseudo-rotaxane for the use as an Alzheimer?s disease biosensor.

Subject Area

Organic chemistry

Recommended Citation

Scott MacGill Karas, "The synthesis of rotaxane probes for magnetic resonance imaging (MRI)" (2016). Dissertations and Master's Theses (Campus Access). Paper AAI10239074.