A study of the increased risk of bleeding events in patients with blood clotting disorders, associated with antidepressant medication use

Adam Ehrenborg, University of Rhode Island

Abstract

Background: Patients with blood clotting disorders have severely depleted levels of blood clotting factor (BCF) proteins in their blood, which results in a significantly higher risk of bleeding events than a typically healthy patient. Serotonin based antidepressant medications, such as selective serotonin reuptake inhibitors (SSRI) or serotonin norepinephrine reuptake inhibitors (SNRI) alters the levels of serotonin in the blood as a mechanism to treat depression. ^ Serotonin is used for many different chemical processes within the body including blood aggregation. We sought to quantify the potential risk associated with the use antidepressant medications to patients with blood clotting disorders. ^ Objective: To determine if patients with BCF disorders who are prescribed SSRI or SNRI medications are at an increased risk of having a major bleeding event. (Abstract shortened by ProQuest.)^

Subject Area

Epidemiology

Recommended Citation

Adam Ehrenborg, "A study of the increased risk of bleeding events in patients with blood clotting disorders, associated with antidepressant medication use" (2016). Dissertations and Master's Theses (Campus Access). Paper AAI10103238.
http://digitalcommons.uri.edu/dissertations/AAI10103238

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