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With the frequency and magnitude of disasters on the rise, millions of people suffer huge losses every year. Scholars have recently proposed various frameworks in disaster relief management in order to guide the research in this field. Although successful disaster relief requires the entire humanitarian supply chain to respond in harmony, it is surprising that there exists no humanitarian relief framework drawn from the perspective of supply chain management. In this article, we create a new research framework for Humanitarian Supply Chain Management (HSCM) that is complimentary but distinct from commercial supply chain management (CSCM) frameworks. The framework we developed offers a new lens for humanitarian researchers. We also conduct a systematic literature review in this field and identify some opportunities for future research. The results strongly suggest the need for additional empirical research to test the existing concepts and models. Second, there is evidence that research focusing on “upstream” relief chain has been neglected relative to “downstream”. Additionally, due to its rapid advancement, information technology related research opportunities in this field would always be there.