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Theses/Dissertations from 2017

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Biotransformation and Pharmacokinetic Evaluation of PF-5190457, A Novel Drug Candidate for Alcoholism, Sravani Adusumalli

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The Physiological Glucagon Receptor in Rat Heart, Kevin Agostinucci

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Concomitant Use of Central Nervous System Stimulants and Depressants Prescribed in Rhode Island, Aram Babcock

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Conformational Insights Into Aminobiphenyl-Modified DNA: Implications for Mutation and Repair, Ang Cai

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Using Natural Products to Treat Resistant and Persistent Bacterial Infections, Robert W. Deering

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Predictors of Infection in Rheumatoid Arthritis Patients Using Anti-Tumor Necrosis Factor Agents, Tasia Liu

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Circadian Rhythm: A Functional Connection Between SHP and DEC1 Transcription Factor, Marek Matczynski Marczak

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Novel Pharmacological Action of Clozapine at D2 Dopamine Receptors, Joseph Michael Schrader

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CES Involved Inhibition and Regulation, Yuanjun Shen

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Novel Methods for Delivering and Promoting the Endosomal Escape of Nucleic Acid Based Drugs: Chiral Polyamines and Hydrophobic Nanoparticle-Containing Liposomes, Ruchi Verma

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Flavin-Containing Monooxygenase-3 and 5: Tissue Distribution, Age-Related Expression and Regulation by Endoplasmic Reticulum Stress, Zhen Xu

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Cardiovascular Adverse Events in Patients Receiveing QT Interval Prolonging Medications, Yizhou Ye

Theses/Dissertations from 2016

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Effect of Disease State on Human Carboxylesterase 1 Expression and Activity, Abdullah Aljutayli

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Healthcare Costs and Impact of Medication Adherence on Outcomes in Patients on Novel Anticoagulant Therapy, Chinmay Deshpande

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Retrospective Cohort Study of Tobacco Dependence Treatment Patterns in a US Commercially Insured Population, Elizabeth Anne MacLean

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Isolation, Synthesis, and Metabolism of Polyphenols: Stilbenoids, Gallotannins and Ellagitannins, Daniel B. Niesen

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Antimicrobial Resistance Patterns and Protective Effects of Statins in Bacteremic Patients, Ajinkya Pawar

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Investigations on Biologically Active Carbohydrates from Natural Sources, Jiadong Sun

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Measuring Adherence with Antidepressant Medication: Comparison of HEDIS and PDC Methodologies, Carmen Monica Telinoiu

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Cadmium Contributes to Breast Cancer Development by Influencing Cell Adhesion Network, Zhengxi Wei

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Bile Acids and Premature Labor in Intrahepatic Cholestasis of Pregnancy, Sangmin You

Theses/Dissertations from 2015

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NRF as an Oxidative Stress and Nutrient Responsive Transcription Factor in Calorie Restriction, Laura Armstrong

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Synthesis of 2-Amino-α-Carboline and Analogues Relevant for Structural Investigations of the Corresponding DNA Adducts, Matthew S. Blake

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Tolfenamic Acid: A Potential Modifier of Tau Protein in Alzheimer's Disease, Joanna K. Chang

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CHEMICAL INVESTIGATION OF CANDIDATE PROBIOTICS IN AQUACULTURE AND FORMULATION OF A PROBIOTIC AGENT FOR OYSTER LARVICULURE, Christine Anh Dao

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Therapeutic Drug Monitoring of Immunosuppresive, Mwlod A. Ghareeb

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DEVELOPMENT OF COPPER SULFIDE NANOPARTICLES FOR PHOTOTHERMAL AND CHEMO THERAPY OF CANCER CELLS, Yajuan Li

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EVALUATION OF IN VITRO ANTI-INFLAMMATORY, ANTI-DIABETIC AND ANTI-LIPOGENIC ACTIVITY OF NATURAL POLYPHENOLIC EXTRACTS AND THEIR PURE CONSTITUENTS, Pragati P. Nahar

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EFFECTS OF PERFLUORINATED COMPOUNDS (PFCs) ON METABOLIC TISSUES AND THE BENEFITS OF CALORIC RESTRICTION, Deanna M. Salter

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Role of Nuclear Factor E2 Related Factor 2 (Nrf2) in Environmental Chemical Induced Steatosis and Adipogenesis, Prajakta Shimpi

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GARCINIA KOLA: PHYTOCHEMICAL, BIOLOGICAL AND FORMULATION STUDIES, Yasah Vezele

Theses/Dissertations from 2014

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MOLECULAR INTERACTION IN CARBOXYLESTERASES-BASED CATALYSIS: ONTOGENIC EXPRESSION AND INDUCTION THROUGH A NOVEL ELEMENT, Yi-Tzai Chen

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MEASURING AND PREDICTING THE FACTORS ASSOCIATED WITH PERSISTENCE TO ANTIDEPRESSANT THERAPY IN PATIENTS WITH DIABETES, Harini Chinthapatla

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FACTORS ASSOCIATED WITH SUBOPTIMAL SAFETY LABORATORY OF METFORMIN THERAPY, Yu Seon Jung

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PHYTOCHEMICAL INVESTIGATION OF THE TRADITIONAL BOTANICAL MEDICINE IRESINE CELOSIA, Caroline Grace Killian

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PHYTOCHEMICAL AND BIOLOGICAL INVESTIGATION OF GALLOTANNINS FROM RED MAPLE (ACER RUBRUM) SPECIES, Hang Ma

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LIPOSOMES FOR THE CONTROLLED DELIVERY OF MULTIPLE DRUGS, Swapnil A. Malekar

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THE EVALUATION OF DOCTOR OF PHYSICALTHERAPY STUDENTS’ CONFIDENCE AND SATISFACTION USING HUMAN PATIENT SIMULATION, Brooke O'Connell

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DESIGN AND EVALUATION OF 5′-O-DICARBOXYLIC AND POLYARGININE FATTY ACYL DERIVATIVES OF ANTI-HIV NUCLEOSIDES, Bhanu Priya Pemmaraju Venkata

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EVALUATING THE ROLE OF HYPOGLYCEMIA & COMORBID ILLNESS ON DIABETES MANAGEMENT BEHAVIORS, Saumitra Vijay Rege

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SYNTHESIS AND EVALUATION OF AMPHIPHILIC PEPTIDES AS NANOSTRUCTURES AND DRUG DELIVERY TOOLS, Naser Ali Sayeh

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EPIGENETIC MODIFICATION AND ANALYSIS OF NATURAL PRODUCT GENE CLUSTERS TO ENHANCE DRUG DISCOVERY FROM BACTERIA, Justin D. Schumacher

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TRANSCRIPTIONAL REGULATION OF ALDO-KETO REDUCTASE 1D1, Leila Valanejad

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CADMIUM PROMOTES PROLIFERATION OF TRIPLE-NEGATIVE BREAST CANCER CELLS THROUGH EGFR-MEDIATED CELL CYCLE REGULATION, Zhengxi Wei

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STRUCTURAL AND CONFORMATIONAL INSIGHTS INTO BULKY ARYLAMINE-INDUCED MUTAGENESIS, Lifang Xu

Theses/Dissertations from 2013

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Pharmacodynamic Mechanisms of Tolfenamic Acid Induced SP1 Degradation Relative to Alzheimer's Disease Pathology, Lina I. Adwan

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Applying QbD and Pat in Biological Manufacturing for “Continued Process Verification”, Prakash Bedre

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Trends in the Use of Preventive Care by Women in the U. S. General Population, Erin Bennett

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Phytochemicals from the Roots of Northern Highbush Blueberry (Vaccinium Corymbosum), Amanda Cirello

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Effect of Metabolic Disease and Xenobiotic Exposure on Hepatic ATP-Binding Cassette (ABC) Drug Transporter Expression, Ajay Chowdary Donepudi

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Sequence Effects on the Repair and Replication of Arylamine-DNA Adducts, Vipin Jain

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Predictors of Non-Vaccination Against Human Papillamovarius Among Us Women Aged 18-26, H. Elsa Larson

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Prediction of Heptatic and Renal Clearance in Pediatric Populations: A "Bottom-Up" Approach Versus "Top-Down" Recognition of Covariates, Hong Lu

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Model-Based Approaches to Characterize Clinical Pharmacokinetics of Atorvastatin and Rosuvastatin in Disease State, Joyce Macwan

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Role of Nuclear Factor E2 Related Factor 2 (NRF2) in Development of Steatosis and Drug Transporter Alterations, Vijay RS More

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Cyclic Peptides: Design, Characterization, Self-Assembly, and Applications as Nano Drug Delivery Systems, Amir Nasrolahi Shirazi

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Use and Unintended Consequences of Antidepressant Medications by Depressed Older Adults, Eun Sun Noh

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Compounds from A. Platanoides Bark, V. Corymbosum Roots & Topical Formulations using Maple Syrup, Raed Omar

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Structural and Conformational Probing of 2-Acetylaminofluorene-Modified -1, -2 and -3 Slipped Mutagenic Intermediates, Anusha Sandineni

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Structure and Thermodynamic Insights on Acetylaminofluorene-Modified Deletion DNA Duplexes as Models for Frameshift Mutagenesis, Anusha Sandineni

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Producing In-Situ Nanoparticles of Griseofulvin using Supercritical Antisolvent Methodology, Pratik Sheth

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Effect of Manufacturing Methods Used in the Stability of Amorphous Solid Solutions and Predictions to Test them, Kaoru Tominaga

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Suppression of PXR Expression by Endoplasmic Reticulum Stress and Microrna, Thaveechai Vachirayonstien

Theses/Dissertations from 2011

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THE FORMULATION OF NATURALLY OCCURING POLYPHENOLIC NUTRACEUTICAL AGENTS USING HOT-MELT EXTRUSION, Aditya Duvuri

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BIOFILM PRODUCTION BY CLINICAL STAPHYLOCOCCUS AUREUS AND ITS INHIBITION BY HYPERICUM METABOLITES, Simon Antranik Sarkisian

Theses/Dissertations from 2008

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Tolfenamic Acid Interrupts the De Novo Synthesis of Plaque-Forming Amyloid Beta Peptides: Implications for Alzheimers Disease, Lina I. Adwan

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In Vitro Effects of Emollient Substances on Release of Ketorolac Tromethamine, Burcak Alioglu

Theses/Dissertations from 2006

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Identification and Minimization of Protein Loss During the Manufacturing of a Beta Domain Deleted Recombinant Human Factor VIII, Cyrus Agarabi

Theses/Dissertations from 2004

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POPULATION PHARMACOKINETICS OF CYCLOSPORINE IN HEART AND LUNG TRANSPLANT PATIENTS, Gautam Baheti

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ENHANCEMENT OF CARBAMZEPINE SOLUBILITY USING SELECTED WATER SOLUBLE POLYMERS AND A SOLID DISPERSION TECHNIQUE, Sameer Late

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BIOACTIVE SECONDARY METABOLITES PRODUCED BY MARINE MICROORGANISMS: THEIR ISOLATION, STRUCTURAL ELUCIDATION AND FUNCTION, Jiayuan Liu

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MEDICATION PRESCRIBING IN HEART FAILURE: TRENDS IN DRUG TREATMENT AND EVIDENCE FROM THE PAST TEN YEARS, Gregory A. Low

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A MECHANISTIC STUDY TO IDENTIFY PHYSICALLY STABLE AMORPHOUS SOLID DISPERSION, Madhav Vasanthavada

Theses/Dissertations from 2003

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QUANTIFICATION OF INJECTABILITY OF A NEW SELF-ADMINISTERED INTRAMUSCULAR INJECTION, Roja Anandakumar

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EXAMPLES OF POPULATION PHARMACOKINETIC MODELING IN DRUG DEVELOPMENT USING NONMEM, Julie M. Jones

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HEALTH-RELATED QUALITY OF LIFE AS PREDICTOR OF ADHERENCE WITH ANTIRETROVIRAL MEDICATION, Rakesh Joshi

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THE DEC1 TRANSCRIPTION FACTOR: ONCOGENIC INVOLVEMENT AND MOLECULAR MECHANISMS ON TRANSCRIPTION REGULATION, Yuxin Li

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COPING WITH HUMAN IMMUNODEFICIENCY DISEASE AS PREDICTOR OF ADHERENCE WITH ANTIRETROVIRAL MEDICATION, Saurabh Mistry

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TRAZODONE HYDROCHLORIDE CONTROLLED RELEASEMATRIX AND MATRIX-MINI TABLETS, Kiran Penumatcha

Theses/Dissertations from 2002

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MECHANISTIC STUDIES TO ELUCIDATE THE ROLE OF LIPID VEHICLES ON SOLUBILITY, FORMULATION AND BIOA VAILABILITY OF POORLY SOLUBLE COMPOUNDS, Inayet Dumanli

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EFFECT OF pH AND TEMPERATURE ON CONFORMATIONAL CHANGES OF A HUMANIZED MONOCLONAL ANTIBODY, Sejal Gandhi

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EFFECT OF CRYSTALLINE TO AMORPHOUS CONVERSIONS ON SOLUBILITY OF CEFUROXIME AXETIL, Tooba Murshedkav

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LECITHIN ORGANOGEL-BASED SYSTEM FOR TOPICAL APPLICATION OF KETOROLAC TROMETHAMINE, Angela Attar Nasseri

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PARTICLE FORMATION BY RAPID EXPANSION OF SUPERCRITICAL SOLUTIONS, Chandra S. Vemavarapu

Theses/Dissertations from 2001

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DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL ANTIMICROBIAL PEPTIDES, Khaled Elsaid

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INHIBITION STUDIES OF PROTEIN PHOSPHATASE 2A BY KNOWN CATHARTIC PLANT DRUGS, Michael Ford

Theses/Dissertations from 2000

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INAPPROPRIATE MEDICATION USE IN AN ELDERLY NURSING HOME POPULATION, Jyotsna Dhall

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RELATIVE IMPACT OF VARIOUS SOURCES OF PHARMACOKINETIC AND PHARMACODYNAMIC VARIABILITY ON WARFARIN RESPONSE, Shashikanth Gannu

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DEVELOPMENT, CHARACTERIZATION AND EVALUATION OF A PULSED-RELEASE TABLET DOSAGE FORM FOR LOW DOSE WATER SOLUBLE DRUGS, Suresh Palaniswamy

Theses/Dissertations from 1999

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CHARACTERIZATION OF A PUTATIVE TRANSCRIPTION FACTOR, Maowen Hu

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THE APPLICATION OF THE POPULATION APPROACH TO PHARMACOKINETICS IN DRUG DEVELOPMENT, Kimberley Anne Jackson

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PHARMACODYNAMIC PARAMETERS: INFLUENCE ON DOSE-RESPONSE RELATIONSHIP AND ESTIMATION, Suzette F. Rashed

Theses/Dissertations from 1998

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LIDOCAINE METABOLISM IN ENDOTOXIN INDUCED SEPSIS, Judah Boulet

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CHARACTERIZATION OF GELLING PHENOMENON OF A LIPID BASED FORMULATION, Inayet Dumanli

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CONTROLLED DRUG DELIVERY FROM A NOVEL INJECTABLE IN SITU FORMED BIODEGRADABLE PLGA MICROSPHERE SYSTEM, Rajeev Jain

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THE DEVELOPMENT, CHARACTERIZATION AND EVALUATION OF A NOVEL MULTI-UNIT ERODING MATRIX SYSTEM FOR POORLY SOLUBLE DRUGS, Ketan Arvind Mehta

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A STUDY OF THE RHEOLOGICAL PROPERTIES OF SOME OF THE GELS COMMONLY USED IN THE PHARMACEUTICAL, FOOD AND COSMETIC INDUSTRIES AND THEIR INFLUENCE ON MICROBIAL GROWTH, Jorge A. Mendoza

Theses/Dissertations from 1997

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EFFECTS OF MOLECULAR WEIGHT, POLYDISPERSITY AND SOLUTION VISCOSITY OF CELLULOSE ACETATE BUTYRATE ON PROPERTIES AND RELEASE CHARACTERISTICS OF ASCORBYL PALMITATE MICROCAPSULES, Hao-Ying Kung

Theses/Dissertations from 1995

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THE EFFECTS OF METHYLENE BLUE PRETREATMENT ON GLOBAL ISCHEMIA IN THE ISOLATED RAT HEART, Stephen Robert Gorman

Theses/Dissertations from 1994

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FORMULATION OF AN ORAL MODIFIED RELEASEDOSAGE FORM OF AN ADRENERGIC DRUG, Suresh Palaniswamy